Meta-analysis of ¹H-MRS glutamate profiles in adult schizophrenia spectrum disorders and autism spectrum disorder: Study protocol.

ABSTRACT:

Background

Schizophrenia spectrum disorders (SSDs) and autism spectrum disorder (ASD) share social-cognitive deficits, genetic architecture, and overlapping animal models, yet the neurochemical signatures that differentiate them remain unclear. This protocol describes a systematic review and meta-analysis of proton magnetic resonance spectroscopy (¹H-MRS) studies examining glutamate, glutamine, and their combined signals. The primary aim is to establish a human neurochemical benchmark to guide translational research.

Methods

Eligible studies will be those measuring ¹H-MRS glutamatergic metabolites at ≥3 T field strength in at least one of five brain regions: anterior cingulate cortex, dorsolateral prefrontal cortex, hippocampus, striatum, or thalamus. A

SUBMITTER: Takahashi Y 

PROVIDER: S-EPMC12670971 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature