A comparison of clinical, lesion-based and connectome-based models of post-stroke depression: a prospective longitudinal study.

ABSTRACT: Post-stroke depression (PSD) is a frequent and disabling complication of ischemic stroke. Although clinical risk factors of PSD are well-established, the added predictive value of lesion and connectome-based brain-symptom mapping methods remains unclear. This study aimed to compare the predictive performance of clinical, lesion based, and network-based models of 3-months PSD in patients with minor ischemic stroke. We conducted a prospective longitudinal study including 263 patients with recent ischemic stroke. Clinical, radiological, and psychometric data were collected at baseline and at 3-month follow-up. Structural lesions were segmented on acute MRI and used to generate disconnectome maps and compute graph-theory metrics. Depressive symptoms severity at 3 months were measured using the

SUBMITTER: Borderies N 

PROVIDER: S-EPMC12671036 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature