Antimicrobial activities of quaternary phosphonium-type small molecular antibacterial materials against methicillin-resistant <i>Staphylococcus aureus</i>.

ABSTRACT: Methicillin-resistant Staphylococcus aureus (MRSA) has become a significant public health concern due to its resistance to most antibiotics and its ability to form persistent biofilms, complicating treatment strategies. The need for new and effective antibacterial agents that can overcome these challenges is urgent. In this study, we address this issue by synthesizing and evaluating five quaternary phosphonium-type small molecular antibacterial agents ([MTPP]·I, [ETPP]·I, [ITPP]·I, [BTPP]·I, and [PTPP]·I) against MRSA. Our findings show that as the alkyl chain length of the phosphonium compounds increases, their antibacterial activity significantly improves, with [PTPP]·I exhibiting the highest efficacy. This compound demonstrated a minimum inhibitory concentration (MIC) of 16 µg/mL

SUBMITTER: Deng J-W 

PROVIDER: S-EPMC12671080 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature