A presumed mouse parvovirus with overlooked high toxicity for human primitive CD34⁺ hematopoietic precursors <i>in vitro</i> and in bone marrow-humanized mice.

ABSTRACT: Two strains of the minute virus of mice (MVM) parvovirus (of the species Protoparvovirus rodent1), named i (immunosuppressive) and p (prototype), show disparate tropism and pathogenicity in mice. Unlike the virulent MVMi, the MVMp is attenuated and infection-restricted in primary mouse hematopoietic cells; however, it does infect human transformed, established, and stem cells. We thus seek here a putative MVMp natural tropism to humans compared to MVMi. Infectious purified MVMp virions suppress in vitro the clonogenic potential of human committed (erythroid and myeloid) and primitive CD34⁺ progenitors, regardless of the cell source (umbilical cord blood, G-CSF mobilized peripheral blood, or bone marrow), in a multiplicity of infection-dependent manner. Furthermore,

SUBMITTER: Segovia JC 

PROVIDER: S-EPMC12671093 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature