Analysis of gut microbiota in patients with AVS and identification of potential biomarkers: a cross-sectional study.

ABSTRACT: This study evaluated the characteristics of the gut microbial (GM) in patients with aortic valve stenosis (AVS). Thirty patients diagnosed with AVS and 30 healthy controls (HC) were included. Fecal samples were obtained for high-throughput 16S rDNA sequencing. Bacterial diversity was assessed using QIIME and R software. Potential biomarkers were identified using the random forest model. The model performance was evaluated using receiver operating characteristic (ROC) curves and decision curve analysis. Relationships between the GM and clinical characteristics of participants were examined using the Spearman's correlation. The composition of GM, measured by beta diversity, significantly differed between the two groups (Adonis, P = 0.001), indicating distinct microbial community struc

SUBMITTER: Jiang F 

PROVIDER: S-EPMC12671120 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature