Antimicrobial peptides disrupting the bacterial membrane reduce <i>Salmonella</i> colonization in chickens.

ABSTRACT: Salmonella is a significant food safety and public health concern. Poultry products have been considered the main vehicles of Salmonella infections in humans. Salmonella being present in visually healthy poultry is suggested as the preeminent human transmission risk factor, allowing bacteria to easily transmit from eggs and poultry to humans. Antimicrobial peptides (AMPs) have been suggested as promising alternatives to current antibiotics because of their low propensity for resistance development. In this study, we tested the efficacy of Lactobacillus rhamnosus GG (LGG)-derived small peptides (P1-NPSRQERR, P2- PDENK, and P4-MLNERVK) against Salmonella Typhimurium (ST) and Salmonella Enteritidis (SE) both in vitro and in chickens. Peptides i

SUBMITTER: Closs G 

PROVIDER: S-EPMC12671136 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature