HCoV-229E does not trigger early interferon gene expression and evades IFN signaling in human A549 lung epithelial cells.

ABSTRACT: Coronaviruses cause upper and lower respiratory tract infections ranging from mild infections to severe conditions such as pneumonia and acute respiratory distress syndrome (ARDS). One factor contributing to the pathogenesis of viral infection is the ability to avoid or downregulate the activation of interferon (IFN)-induced antiviral immunity. We show that the seasonal human coronavirus HCoV-229E readily replicated in human lung A549 and human hepatoma Huh7 cells, but the infection did not induce type I or type III IFN gene expression and IFN-induced MxA expression. Total cellular RNA isolated from HCoV-229E-infected A549 or Huh7 cells transfected into uninfected A549 cells failed to induce significant IFN gene expression, indicating that HCoV-229E RNA is likely not recognized by RIG-I-li

SUBMITTER: Lundberg R 

PROVIDER: S-EPMC12671147 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature