Staphyloxanthin-enriched extracts promote biofilm formation and oxidative stress resistance in <i>Staphylococcus aureus</i>.

ABSTRACT: Staphylococcus aureus, an opportunistic pathogen of global health concern, presents a significant clinical challenge due to its escalating antibiotic resistance and biofilm-forming capacity. The biofilm matrix of S. aureus is enriched with carotenoids, primarily staphyloxanthin (STX), which function as virulence factors by scavenging reactive oxygen species and inhibiting antimicrobial peptides. In this study, we examined the impact of the methanol extract of S. aureus (MES) on biofilm formation. Our findings revealed that MES enhanced biofilm formation in S. aureus strains with inherently weak biofilm-forming ability by upregulating key adhesion genes (fibronectin-binding protein A/fnbB, serine-aspartate repeat-containing protein D, clumping factors A/B,

SUBMITTER: Yu J 

PROVIDER: S-EPMC12671152 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature