Cycloserine-induced neuropsychiatric toxicity in multidrug-resistant tuberculosis: association with peak plasma concentration.

ABSTRACT: Cycloserine (Cs) is a crucial anti-multidrug-resistant tuberculosis medication with significant clinical efficacy. However, its clinical application is limited by neuropsychiatric-related adverse drug reactions (ADRs). This study retrospectively evaluated the peak plasma concentration (C_max) of Cs and Cs-related neuropsychiatric ADRs and analyzed the risk factors of developing neuropsychiatric ADRs. A multivariable ordinal logistic regression model was built to predict the incidence of neuropsychiatric ADRs. This study enrolled a total of 136 participants, with a cumulative incidence of neuropsychiatric ADRs of 12.5%. Patients experiencing ADRs had significantly higher Cs C_max compared to those without ADRs. The risk of ADRs rose with increasing Cs expos

SUBMITTER: Cheng J 

PROVIDER: S-EPMC12671155 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature