Gallic acid inhibits EMCV infection via targeting the interaction between TBK1 and IRF3 to promote IFN-β expression.

ABSTRACT: Encephalomyocarditis virus (EMCV) is an important zoonotic pathogen with global distribution, which has caused huge serious economic losses to the development of the livestock industry. Gallic acid (GA) is an active ingredient of traditional Chinese medicine with wide pharmacological and biological activities and is also a potential antiviral drug. However, its antiviral effect and mechanism of anti-EMCV are still unclear. In the present study, we found that therapeutic administration of GA could significantly reduce the viral load and viral titer of EMCV to inhibit EMCV replication in a dose-dependent manner. GA could also protect cells infected by EMCV and decrease the content of capsid protein VP1 of EMCV in HEK-293 cells. Additionally, the mechanistic investigations revealed that GA mi

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12671161 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature