Dynamics of the respiratory infectome in children with community-acquired pneumonia: insights from large and short time-scale analyses.

ABSTRACT: Community-acquired pneumonia (CAP) has emerged as a significant health challenge for young children, especially after the relaxation of COVID-19 restrictions, which coincided with a sharp increase in CAP cases. While pathogen profiling is commonly performed, comprehensive studies examining the total infectome and its dynamic changes during disease progression and in relation to the pandemic remain scarce. To address this gap, we conducted a prospective cohort study involving 58 children hospitalized with CAP in Wuxi, China, during and after COVID-19 control measures. Sputum samples were analyzed using metagenomic and metatranscriptomic sequencing to characterize the total infectome. Results showed that RNA sequencing offers a more comprehensive view of the infectome, while DNA sequencing e

SUBMITTER: Liao Y 

PROVIDER: S-EPMC12671164 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature