Pangenome analysis of Tanzanian clinical <i>Klebsiella pneumoniae</i> reveals pandemic clones with high genome plasticity and versatile mobilome, virulome, and resistome profiles.

ABSTRACT: Klebsiella pneumoniae is a rapidly evolving pathogen with a diverse pangenome whose mobilome and resistome remain elusive. Here, we aimed to delineate the pangenome of 198 isolates from Tanzanian regions. Raw Illumina reads retrieved from public repositories were assembled and analyzed using multilocus sequence typing, core-genome single nucleotide polymorphism (SNP)-based phylogeny, and capsular polysaccharide (K-locus) and lipopolysaccharide O-antigen (O-locus) typing. A total of 184 isolates were classified as Klebsiella pneumoniae sensu stricto, while 14 belonged to other species within the Klebsiella pneumoniae complex. We identified 90 sequence types (STs), including global high-risk ST45, ST39, ST336, ST14, ST1552, and ST17. KL24 and KL25 were the most common K-

SUBMITTER: Bahati SY 

PROVIDER: S-EPMC12671191 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature