Maternal gut microbiota transmission and early-life colonization patterns influence infant CMPA risk.

ABSTRACT: The establishment of gut microbiota in early life represents a critical window for immune system development and the prevention of cow's milk protein allergy (CMPA). While maternal influence on infant gut colonization is well-documented, the specific relationship between maternal-infant microbiota patterns and CMPA development remains poorly understood. In this study, we analyzed 106 fecal samples from maternal-infant pairs, including 16 complete triads (maternal, newborn, and 3-month infant samples), using 16S rRNA sequencing to identify key bacterial markers associated with CMPA risk. Our findings revealed distinct temporal colonization patterns, with initial Staphylococcus dominance in newborns shifting to Bifidobacterium predominance by three months, a trend particularly

SUBMITTER: Zhang L 

PROVIDER: S-EPMC12671192 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature