Niclosamide nanoparticles as a novel adjuvant reverse colistin resistance via multiple mechanisms against multidrug-resistant <i>Salmonella</i> infections.

ABSTRACT: The mobile colistin resistance (mcr) mechanism enables rapid horizontal transfer of resistance genes across food, animals, and humans, driving significant resistance in mcr-carrying bacteria. While numerous adjuvants can reverse colistin resistance, research on their dose-response relationships remains limited, and most suffer from poor solubility, low bioavailability, and safety issues, hindering clinical use. The dose-response analysis showed that niclosamide could achieve a high reversal efficiency within a relatively low concentration range. However, as the concentration of niclosamide increased, the ability to reverse colistin resistance remained unchanged, and the reversal efficiency gradually decreased. Mechanistic analyses reveal that its synergistic antibacterial eff

SUBMITTER: Yi K 

PROVIDER: S-EPMC12671199 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature