Transiently produced IgGs enable universal SARS-CoV-2 diagnosis and differentiation recent from past infections.

ABSTRACT: Early diagnosis and differentiating infected from vaccinated animals (DIVA) are the milestone in mitigation, control, and eradication of virus. However, the continuous evolution of new virus strains has hindered the success of many classical techniques, and no DIVA-compatible vaccines are available for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We here develop a universal diagnostic protein-peptide hybrid microarray (PPHM) for different SARS-CoV-2 strains infections and extend the DIVA concept to differentiate recently infected from historically vaccinated/infected hosts (DIVH) in the context of SARS-CoV-2 using in a single sample. First, we analyzed the amino acid sequence identities, which exceeded 96.6%, among the SARS-CoV-2 strains-Delta, Omicron, and New Omicron-and

SUBMITTER: Li C 

PROVIDER: S-EPMC12671204 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature