Unveiling the emergence of community-acquired methicillin-resistant <i>Staphylococcus aureus</i> (CA-MRSA) in Chinese hospitals with remarkable genetic diversity: a multicenter molecular epidemiological investigation.

ABSTRACT: To understand the prevalence and phylogeny of methicillin-resistant Staphylococcus aureus (MRSA) in Chinese hospitals and identify the dominant MRSA lineages causing hospital infections, we collected 101 S. aureus isolates from multiple centers across China, tested their antibiotic sensitivity, and performed whole-genome sequencing. Using our group's database, a core genome-based phylogenetic analysis of 204 S. aureus isolates was conducted. The results revealed an interspersed distribution of MRSA and MSSA without distinct clade separation. CC59-ST59-t437-SCCmec IV was identified as the predominant community-associated MRSA (CA-MRSA) clone widely distributed across cities, while hospital-associated MRSA (HA-MRSA) was mainly composed of CC5-ST5-SCC

SUBMITTER: Tu S 

PROVIDER: S-EPMC12671212 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature