Citrulline-enhanced chicken resistance to <i>Salmonella Enteritidis</i> infection via urea cycle modulation and nitric oxide production.

ABSTRACT: Salmonella Enteritidis infection has caused substantial economic losses in the poultry industry. Traditional antibiotic treatments have led to issues, such as drug-resistant bacteria and antibiotic residues, which pose significant threats to human and animal health, as well as food and environmental safety. Therefore, establishing new, effective prevention and control methods is of paramount importance. In this study, we utilized gas chromatography-mass spectrometry (GC-MS) metabolomics to analyze the metabolomic profiles of chickens infected with varying concentrations of Salmonella Enteritidis. Significant differences in the metabolomes were observed, with citrulline identified as a candidate biomarker, showing increased levels corresponding to higher infection doses. Exoge

SUBMITTER: Jiang M 

PROVIDER: S-EPMC12671226 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature