Lipid nanoparticle-delivered mRNA vaccine encoding the MOMP of <i>Chlamydia psittaci</i> elicits protective immune responses in BALB/c mice.

ABSTRACT: Chlamydia psittaci is an important pathogenic zoonotic pathogen that infects birds and can be transmitted to humans and other animals. This research focused on creating an mRNA vaccine targeting C. psittaci and assessing its immunogenic and protective effects in BALB/c mice. We carried out a trial to prepare and assess an mRNA vaccine targeting C. psittaci. This study involves an mRNA vaccine encoding the major outer membrane protein (MOMP), produced via an in vitro transcription system and encapsulated in lipid nanoparticles (LNPs). The mRNA vaccine was constructed by synthesizing non-replicating mRNA encoding MOMP. LNPs were produced and characterized for their particle morphology, size, and cytotoxicity. Histopathological analysis and indirect immunofluoresce

SUBMITTER: Wang B 

PROVIDER: S-EPMC12671227 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature