ABCC11 Earwax Trait and Genotype Are Suitable Tools for Introductory Labs to Learn Genetics and Molecular Techniques.

ABSTRACT: Professional experiments in genetic research usually start in a class at university. However, interest in genetic research techniques from an early age is essential. We have continuously performed a short genetic experimental course for high school students using a simple molecular experiment and computer-based learning for Mendelian inheritance. We utilized the phenotype-genotype association of ABCC11 polymorphism (rs17822931), in which the A allele at rs17822931 of ABCC11 is the recessive genotype for the dry earwax phenotype. Conversely, the G allele is the dominant genotype for the wet earwax phenotype. The phenotype is primarily determined by a single-nucleotide polymorphism (SNP), rs17822931, with the A or G allele, which has global prevalence with few exceptions. The A or G allele i

SUBMITTER: Ohta T 

PROVIDER: S-EPMC12671274 | biostudies-literature | 2025 Nov-Dec

REPOSITORIES: biostudies-literature