Ruthenium coordinated nanohybrids modulate tumor microenvironment and potentiate amplified phototherapy augmented immunotherapy of hypoxic tumor.

ABSTRACT: Hypoxic tumor microenvironment (TME) greatly limits the efficacy of photodynamic therapy (PDT) and immunotherapy. Additionally, small molecule phototherapeutic agents not only require delivery vectors due to their poor water solubility, but also suffer from poor photostability. Herein, we present a synergy of nanocatalysts-amplified PDT, sustained photothermal therapy (PTT) and robust immunotherapy for eliminating hypoxic solid tumor and preventing distant tumor metastasis by constructing the ruthenium coordinated nanohybrids (defined as RuIP) consisting of ruthenium (Ru) ions, phototherapeutic agent (IR825), and polyvinylpyrrolidone (PVP). The coordination driven self-assembly of IR825 with Ru improves the photostability of IR825 and endows it i) with high catalytic O₂ generati

SUBMITTER: Li J 

PROVIDER: S-EPMC12671372 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature