Influence of circadian rhythm on the determination of the IMMune Age indeX (IMMAX).

ABSTRACT:

Introduction

To study the impact of immunosenescence on various biological processes the determination of the immune age has gained much interest in recent years. Based on easily determined five immune cell components we recently developed the IMMune Age indeX (IMMAX) as a biomarker for immunosenescence. However, the influence of the circadian rhythm of immune cell concentrations in peripheral blood on the determination of the IMMAX was unclear.

Methods

Therefore, we conducted an experimental study with 50 participants aged 20-69 years and took blood samples at 8 a.m., 1 p.m. and 6 p.m. to determine the IMMAX over the day. Additionally, the chronotype of the study participants was assessed by D-MEQ questionnaire.

Results

While individual immune cell ratios showed chan

SUBMITTER: Trebing S 

PROVIDER: S-EPMC12671377 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature