Spatial Myeloid Landscape of Large Artery Atherosclerotic and Cardioembolic Thrombi Retrieved by Mechanical Thrombectomy.

ABSTRACT: Cardioembolic (CE) and large artery atherosclerosis (LAA) strokes are two main causes of acute ischemic stroke (AIS), carrying a high risk of recurrence. Studies on the composition of CE and LAA thrombi have produced conflicting results, underscoring the need for further investigation into more effective treatment strategies. While myeloid cells such as neutrophils and monocytes are known to promote thrombosis in cardiovascular diseases, their specific roles in thrombosis across AIS subtypes remain unclear. We enrolled 42 AIS patients undergoing endovascular thrombectomy and retrieved their thrombi. Among 42 AIS patients undergoing endovascular thrombectomy, only thrombi and clinical data from patients with large artery atherosclerosis (LAA, n = 8) or cardioembolic (CE, n = 27) stroke were

SUBMITTER: Jo S 

PROVIDER: S-EPMC12671477 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature