Battling the Conundrum of Bleeding and Clotting: Initiation of Venous Thromboembolism Prophylaxis in Traumatic Brain Injury after Neurosurgical Intervention.

ABSTRACT:

Background

There are no consensus guidelines demonstrating that early venous thromboembolism prophylaxis (VTEP) is safe in patients with traumatic brain injury (TBI) who undergo neurosurgical interventions. We hypothesized that early initiation of VTEP in patients with TBI would decrease the incidence of venous thromboembolism (VTE) and intracranial hemorrhage expansion (ICHE).

Study design

This was a retrospective single-center study of adult patients with TBI who underwent neurosurgical intervention from 2012 to 2023 at a level 1 trauma center. Early (72 hours or less) and late (more than 72 hours) VTEP initiation after neurosurgery were compared. Outcomes were VTE, ICHE, and mortality. A Cox proportional hazard regression was completed comparing late and early and VTEP vs

SUBMITTER: Ratnasekera A 

PROVIDER: S-EPMC12671560 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature