DWI Positivity in Mild, Nondisabling Acute Cerebral Ischemia: Data From the PRISMS Trial.

ABSTRACT:

Background

In patients with acute cerebral ischemia (ACI) and mild deficit, acute infarction on magnetic resonance imaging (diffusion-weighted imaging [DWI]-positivity) is inconsistently detected. Our objective was to characterize the rate of detection in the first dedicated trial of a population with mild, nondisabling stroke and assess the detection and its association with baseline clinical and imaging characteristics. We hypothesized that white matter hyperintensity (WMH) would independently predispose patients to DWI-positivity.

Methods

The phase 3b, randomized, double-blinded PRISMS (Potential of Alteplase for Ischemic Strokes with Mild Symptoms) trial compared administration of intravenous alteplase to aspirin for mild (National Institutes of Health Stroke Scale score

SUBMITTER: Wang LL 

PROVIDER: S-EPMC12671632 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature