Sex-Based Differences in Thrombus Composition in Acute Ischemic Stroke.

ABSTRACT:

Background

Endovascular thrombectomy allows for detailed study of thrombus composition in acute ischemic stroke. Differences in thrombus composition can affect outcomes, and the impact of sex on coagulation physiology is recognized. This study investigates whether thrombus composition in acute ischemic stroke varies between sexes.

Methods

Retrospective study on consecutive endovascular thrombectomy-treated patients with acute ischemic stroke at Niguarda Hospital in 2023. Thrombi were stained with hematoxylin and eosin, and the percentages of fibrin, red blood cells (RBCs), and white blood cells (WBCs) were quantified as proportions of the total thrombus area. Univariate and multivariate analyses were performed to identify histological differences between sexes-multivariate a

SUBMITTER: Schwarz G 

PROVIDER: S-EPMC12671642 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature