Metformin reverses periodontal destruction caused by experimental periodontitis by inhibiting interleukin-1β activity.

ABSTRACT:

Background

Periodontitis is a destructive disease that affects periodontal tissue. While current research focuses on disease management, research on tissue repair remains limited. Metformin, a first-line medication for diabetes treatment, has positive effects on bone health in nondiabetic patients. However, its potential for repairing periodontal tissue remains unclear. Therefore, this study aimed to evaluate the reparative effects of metformin on periodontitis-damaged periodontal tissue in mice.

Methods

A mouse model of periodontal repair was used, in which silk ligatures were removed from the molars after inducing periodontitis, followed by metformin administration. Histomorphometric and histological analyses were conducted to assess comprehensive repair of the periodontiu

SUBMITTER: Wang Z 

PROVIDER: S-EPMC12671693 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature