The citrus tristeza virus p33 protein functions as a viroporin.

ABSTRACT: Viroporins are viral proteins that form ion channels in the membranes of the host and, thus, alter the host ion homeostasis to create more favorable environments for the virus. Since the discovery of the ion channel activity of the M2 protein encoded by influenza virus A (species: Alphainfluenzavirus influenzae), many additional viral proteins have also been characterized as viroporins. However, most viroporins known thus far belong to animal viruses, while the discovery of plant virus viroporins has significantly lagged. In this work, we present evidence that the p33 protein, a membrane-associated protein of citrus tristeza virus (CTV; species: Closterovirus tristezae), possesses the characteristics of a viroporin. We first show the substantial structural similarities between the transmem

SUBMITTER: Aknadibossian V 

PROVIDER: S-EPMC12671738 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature