GalNAc in vaginal secretions: a potential non-invasive risk indicator associated with the risk of premature rupture of membranes.

ABSTRACT: Premature rupture of membranes (PROM) is a major contributor to preterm birth and neonatal morbidity. Current diagnostics are predominantly reactive and detect rupture only after it occurs. In a clinical cohort of 60 pregnant women (20 with PROM, 40 gestational controls at 31-36 weeks), we developed and validated a colorimetric assay for N-acetyl-D-galactosamine (GalNAc) in vaginal secretions. GalNAc levels were significantly lower in the PROM group than in controls, and the assay exhibited linearity, precision, stability, and resistance to interference. Receiver-operating characteristic analysis yielded an AUC of 0.821 (95% CI 0.80-0.97). These data support reduced vaginal GalNAc as a potential non-invasive risk indicator of PROM. While longitudinal validation is required, this approach m

SUBMITTER: Wang L 

PROVIDER: S-EPMC12671759 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature