Topographic analysis of vascular changes in retrograde trans-synaptic degeneration.

ABSTRACT:

Objectives

To investigate the vascular signatures of retrograde trans-synaptic degeneration (RTSD) on OCT and OCTA, and to assess whether these changes differ from those associated with non-arteritic anterior ischemic optic neuropathy (NAION).

Methods

This retrospective cohort study included 24 eyes with RTSD and 12 eyes with NAION. Retinal regions corresponding to visual field defects were topographically defined and compared with anatomically matched internal control regions from the fellow eye. Structural (peripapillary retinal nerve fibre layer(pRNFL), macular ganglion cell-inner plexiform layer(mGCIPL)) and vascular (peripapillary vessel density(pVD], macular vessel density(mVD)) parameters were calculated as affected-to-control ratios (%). Spearman correlation and ANCO

SUBMITTER: Moon Y 

PROVIDER: S-EPMC12671765 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature