Hospital-based care for hallucinogens and risk of mania and bipolar disorder: A population-based cohort study.

ABSTRACT:

Background

Hallucinogen use for both recreational and medical purposes is rapidly increasing globally, raising concerns about potential adverse effects. This study examined the risk of incident mania or bipolar disorder (BD) diagnosis associated with having an emergency department (ED) visit or hospitalization involving hallucinogens.

Methods and findings

We used a population-based cohort study of all individuals aged 14-65 years with no baseline history of BD and registered in the Ontario Health Insurance Plan in Ontario, Canada, between 2008-2022. Incident mania (primary outcome) and incident BD (secondary outcome) were compared between individuals with acute care (an ED visit or hospitalization) involving hallucinogens and the general population using overlap propensity s

SUBMITTER: Myran DT 

PROVIDER: S-EPMC12671790 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature