RIN1 regulates developmental and pain-related plasticity in spinal synapses via NMDA receptor subunit trafficking.

ABSTRACT: Neuronal activity and sensory experience regulate the subunit stoichiometry of synaptic N-methyl-D-aspartate subtype glutamate receptors (NMDARs), a critical determinant for brain development, synaptic plasticity, and a line of neurological disorders. Here we found that Ras and Rab interactor 1 (RIN1), a neuron-specific protein in the brain, played an important role in dictating synaptic NMDAR subunit composition in spinal cord somatostatin-positive (SOM+) neuron, a key component in the spinal circuit transmitting mechanical pain in mice. Our data showed that the protein level of RIN1 was low early after birth, which progressively increased with synapse maturation and promoted the switch from synaptic GluN2B- to GluN2A-containing NMDARs. In adult mice, the nerve injury-induced pathological

SUBMITTER: Bai HH 

PROVIDER: S-EPMC12671805 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature