Pleiotropic function of Dlx5/6 in the development of mammalian vocal and auditory organs.

ABSTRACT: Acoustic communication, a cornerstone of social interactions in mammals, relies on both vocal (effector) and auditory (receptor) organs, which display remarkable morphological diversity across species. The molecular mechanisms supporting the coordinated diversification of effector and receptor systems along with the evolution of species-specific acoustic communication are still poorly understood. A plausible hypothesis is that common genetic pathways orchestrate the parallel morphogenesis of vocal and auditory structures. Here, we addressed this question by generating mutant mice with targeted inactivation of Dlx5/6 genes in the Sox10 lineage, which includes neural crest and otic placode derivatives that contribute to the formation of vocal tract and ear components. We show that Dlx5/6 ina

SUBMITTER: Sanchez-Garrido F 

PROVIDER: S-EPMC12671821 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature