Sensorineural hearing loss in anti-interleukin-1 treated CAPS patients: risk factors and real-life barriers-an observational study.

ABSTRACT:

Objective

To identify modifiable risk factors associated with progression of hearing impairment from a longitudinal cohort of anti-IL-1-treated children and adults with Cryopyrin-Associated Periodic Syndromes (CAPS) and explore real-life barriers to optimal long-term management.

Methods

A single-centre, longitudinal study included consecutive paediatric and adult anti-IL-1-treated CAPS patients with sensorineural hearing loss between 2006 and 2024. Data collected encompassed demographics, disease characteristics, genotype, treatment regimens and hearing assessments using 4PTA, HF-PTA. Primary outcome was WHO grade of hearing impairment at last follow-up. Factors associated with hearing impairment and real-life barriers mandating therapy escalation were identified.

Results

SUBMITTER: Satirer O 

PROVIDER: S-EPMC12671876 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature