Prevalence and functional characterization of anti-interferon autoantibodies in inflammatory myopathies.

ABSTRACT:

Objectives

Functional autoantibodies targeting IFNs can lead to immunodeficiency and have been implicated in various autoimmune diseases. Despite the critical role of interferons in myositis pathogenesis, the significance of anti-IFN autoantibodies in inflammatory myopathies remains poorly understood. This study aimed to investigate the prevalence and functional impact of anti-IFN autoantibodies in patients with myositis.

Methods

Serum samples from 147 patients across two independent myositis cohorts were screened for autoantibodies against IFN-α, IFN-β, IFN-ω and IFN-γ. An independent validation cohort of 34 patients was also assessed for autoantibodies against type I IFN. Functional assays were performed to evaluate whether these autoantibodies inhibited type I IFN-induced

SUBMITTER: Pinal-Fernandez I 

PROVIDER: S-EPMC12671877 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature