A screening tool to detect interstitial lung disease in systemic sclerosis: the ILD-RISC score.

ABSTRACT:

Objectives

As a screening tool for the presence of systemic sclerosis-associated interstitial lung disease (SSc-ILD) on high-resolution computed tomography (HRCT) is missing, we aimed to develop the ILD-RISC score, a risk algorithm to guide physicians in ordering HRCTs, with specific focus on follow-up visits.

Methods

The nominal group technique was used to select items for the multivariable logistic regression with backward selection. The ILD-RISC score was developed from baseline visits of the derivation cohort. After identifying a cut-off favoring sensitivity >85% from the ROC curve, it was validated in a separate cross-sectional cohort, and then applied longitudinally in a specific SSc cohort with negative baseline HRCT.

Results

In the derivation cohort (533 patie

SUBMITTER: Bruni C 

PROVIDER: S-EPMC12671881 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature