Genetic risk and transdiagnostic traits in anorexia nervosa, obsessive-compulsive disorder, and schizophrenia.

ABSTRACT:

Background

Shared genetic risk has been shown across psychiatric disorders. In particular, anorexia nervosa (AN), obsessive-compulsive disorder (OCD), and schizophrenia (SCZ) show shared genetic risk that matches clinical evidence of shared illness and cognitive phenotypes. Given this evidence, we leveraged a large US-based population-based study to determine genetic associations of disorder-specific and shared psychiatric, cognitive, and brain markers and explore whether the latter might be state versus trait markers in eating disorders.

Methods

We used data from the population-based Philadelphia Neurodevelopmental Cohort (N = 4,729) and conducted sex-stratified analyses to test for associations between genetic risk for three disorders (AN, OCD, and SCZ) and mental h

SUBMITTER: Aicoboaie S 

PROVIDER: S-EPMC12671915 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature