Performance of non-invasive prenatal testing in vanishing-twin and multiple pregnancies: results of TRIDENT-2 study.

ABSTRACT:

Objective

To evaluate the performance of non-invasive prenatal testing (NIPT) in vanishing-twin and multiple pregnancies.

Methods

This study was conducted as part of the TRIDENT-2 study, in which NIPT was offered as a first-tier screening test to women with a multiple pregnancy or vanishing-twin pregnancy between 1 June 2020 and 31 March 2023 in The Netherlands. Abnormal NIPT results were investigated by follow-up invasive prenatal testing and/or postnatal genetic testing. Chorionicity, amnionicity and type of vanishing twin were determined on first-trimester ultrasound examination. A vanishing twin was classified as Type I in the presence of an additional empty gestational sac or as Type II when an additional non-viable embryo was observed on ultrasound. The performance of

SUBMITTER: van Eekhout JCA 

PROVIDER: S-EPMC12671934 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature