Identifying critical windows of susceptibility to perinatal lead exposure on child serum vaccine antibody levels.

ABSTRACT: Mounting evidence suggests that early-life lead exposure alters immune system functions, including T-cell-dependent antibody responses to childhood immunizations. However, no studies have identified critical windows of susceptibility to lead exposure. The aim of this study was to identify perinatal critical windows of lead exposure that are associated with antibody responses to anti-MMR (measles, mumps, and rubella virus) and anti-DTP (anti-diphtheria, tetanus, and pertussis toxoids) vaccinations in Hispanic school-aged (mean ± standard deviation: 4.8 ± 0.6 years) children. Weekly lead exposure-from 16 weeks before to 14 weeks after birth-was measured in deciduous teeth from 271 children enrolled in the PROGRESS study. Serum levels of anti-MMR and anti-DTP antibodies were measured by a Lum

SUBMITTER: Colicino E 

PROVIDER: S-EPMC12671974 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature