Body size and occupational physical activity during the life course and gastrointestinal cancers.

ABSTRACT: Evidence is inconclusive regarding the associations of body size and occupational physical activity (PA) during the life course with gastrointestinal cancers. We analyzed data from the Golestan Cohort Study, a population-based, prospective cohort study from Iran, with 50 045 individuals aged 40-75 years enrolled during 2004-2008 and followed through April 2023. Body size during adolescence, early adulthood, and at cohort baseline was assessed using validated pictograms. Large adolescent body size was associated with total gastrointestinal cancers (hazard ratio [HR] = 1.09; 95% CI, 1.02-1.16) and liver cancer (HR = 1.49; 95% CI, 1.11-2.01). Large early-adulthood body size was associated with liver cancer (HR = 1.85; 95% CI, 1.35-2.52). Compared with normal weight during all stages, overweig

SUBMITTER: Sassano M 

PROVIDER: S-EPMC12671977 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature