Effects of aprocitentan on prognostically relevant ambulatory blood pressure-derived variables in resistant hypertension.

ABSTRACT:

Background

Ambulatory blood pressure measurement (ABPM) data from the PRECISION study have shown that in patients with confirmed resistant hypertension (RHT), aprocitentan leads to substantial lowering of BP, particularly at night-time. Here, the ABPM data were used to define subgroups with substantial prognostic value (dipping pattern, BP load, heart rate, arterial stiffness, and salt sensitivity) and to evaluate the BP-lowering effect of aprocitentan on these subgroups.

Methods

The effects of aprocitentan on ABPM derivatives including dipping pattern, BP load, and heart rate were evaluated. The BP lowering effect of aprocitentan was assessed based on the subject's baseline arterial stiffness and salt sensitivity.

Results

At week 4, the placebo-corrected and dose-dep

SUBMITTER: Schlaich MP 

PROVIDER: S-EPMC12672029 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature