Potential role of the spleen in the development of arterial hypertension in humans.

ABSTRACT:

Objectives

Immunity, particularly T lymphocytes, plays an important role in the development of arterial hypertension. Moreover, the so-called neuro-immune axis has been identified as a crucial crossroads, occurring in the spleen and involving placental growth factor as the principal mediator. However, no studies in humans have yet investigated the role of the spleen in hypertension and vascular damage.

Methods

In this retrospective, case-control, single-blind study, we enrolled patients who had previously undergone elective splenectomy (cases) and subjects who had undergone elective cholecystectomy (controls). All subjects underwent 24-h ambulatory blood pressure monitoring, evaluation of retinal arteriole morphology by adaptive optics, capillary density assessment by video-

SUBMITTER: Nardin M 

PROVIDER: S-EPMC12672046 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature