Pseudorabies Virus UL41 Hijacks IFN Response via JAK/STAT Pathway While Cellular TRIM21 Blocks it Through K48 Ubiquitination.

ABSTRACT: Pseudorabies virus (PRV), a significant pathogen that infects various animals, including pigs, encodes multiple proteins that participate in host-pathogen interactions. This study investigates the mechanisms by which PRV evades host immune responses, with a particular focus on the role of the UL41 protein and its interactions with host factors. We found that PRV infection modulates the interferon (IFN) signaling pathway, suppressing the expression of IFN-β and downstream antiviral factors while upregulating IFN-α. However, the direct role of UL41 in IFN-α upregulation remains to be elucidated. The PRV UL41 protein was shown to directly target the JAK/STAT pathway, binding to specific motifs, such as the conserved sequences KUUUCY and CSDGGA, in the untranslated region (UTR) of key mRNAs an

SUBMITTER: Li X 

PROVIDER: S-EPMC12672077 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature