Risk stratification for intracranial infection after high-grade gliomas surgery: a nomogram development and validation study.

ABSTRACT:

Background

Intracranial infection (ICI) is a severe complication following high-grade gliomas (HGGs) surgery, leading to increased morbidity and mortality. This study aimed to identify risk factors for postoperative ICI and to develop and validate a nomogram for predicting its occurrence, providing a tool to guide clinical prevention.

Methods

The clinical data of 104 patients who underwent surgery for HGGs between January 2017 and August 2024 were retrospectively analyzed. Patients were randomly divided into a training set (n=72) and a validation set (n=32). Risk factors for ICI were assessed using univariate and multivariate logistic regression analyses. A predictive nomogram was constructed based on the identified independent risk factors and evaluated for its performance.

SUBMITTER: Liu S 

PROVIDER: S-EPMC12672262 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature