Urinary lipid metabolites and progression of kidney disease in individuals with type 2 diabetes.

ABSTRACT:

Objective

A substantial proportion of individuals with type 2 diabetes (T2D) experience a fast decline (FD) in kidney function, a high-risk phenotype not reliably identified by current clinical markers. This study aimed to evaluate the potential of urinary lipid metabolites as novel predictors for the rapid progression of diabetic kidney disease (DKD).

Methods

This investigation employed a dual-phase design comprising cross-sectional screening and longitudinal validation. In the initial phase, targeted lipidomic profiling of urine samples from 152 patients with T2D and DKD and 152 age- and sex-matched individuals with uncomplicated diabetes revealed distinct metabolite patterns. The subsequent validation phase utilized an independent cohort of 248 T2D patients, in which rapi

SUBMITTER: Xiao Y 

PROVIDER: S-EPMC12672268 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature