Establishment and validation of a prognostic model for nasopharyngeal carcinoma patients based on partial response rates.

ABSTRACT:

Objective

This study aims to investigate the impact of varying rates of partial response (PR) on survival outcomes in nasopharyngeal carcinoma (NPC) patients following induction chemotherapy (IC) and to develop a nomogram for predicting overall survival (OS).

Methods

Clinical data from 561 NPC patients with PR after IC at two institutions between 2014 and 2019 were analyzed using Cox regression. A nomogram was developed and assessed with the concordance index (C-index), calibration curves, Receiver Operating Characteristic (ROC) curves, and Decision Curve Analysis (DCA). Patients were stratified into risk groups based on nomogram scores, followed by the subgroup analyses.

Results

Age, M stage, primary tumor volume post-IC, cervical lymph nodes volume post-IC, lymphocy

SUBMITTER: Wang F 

PROVIDER: S-EPMC12672269 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature