Allergy-unrelated eosinophil activation in the peripheral blood of children with neurodevelopmental disorders.

ABSTRACT:

Background

Neurodevelopmental disorders (NDDs) are increasingly associated with immune dysregulation, but eosinophil activation independent of allergic diseases remains unexplored in this population.

Methods

Peripheral-blood eosinophil cationic protein (ECP) mRNA expression was quantified in 55 children with NDDs-including developmental delay (DD), autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), communication disorder, and tic disorder-and 32 typically developing controls. Participants with allergies or recent infections were excluded.

Results

The NDDs group exhibited significantly elevated ECP mRNA levels compared to controls, with median values of 165.87 copies/μL vs. 56.92 copies/μL (p < 0.001). Subgroup analyses confirmed in

SUBMITTER: Ji W 

PROVIDER: S-EPMC12672305 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature