Hematopoietic stem cell transplantation disrupts age-related gut microbiota signatures in pediatric and adult recipients.

ABSTRACT: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) profoundly reshapes the gut microbiome (GM), yet age-related differences in this process remain incompletely understood. In this study, we analyzed stool samples from a cohort of pediatric and adult patients collected before allo-HSCT and at neutrophil engraftment to assess GM dynamics. We observed a significant reduction in alpha diversity post-HSCT across both age groups, with young patients displaying notably lower biodiversity. While GM composition varies among age ranges before transplantation, these distinctions largely disappeared at neutrophil engraftment, indicating a convergence toward a more uniform "transplant-specific" signature. This shift entailed a loss of health-associated, butyrate-producing taxa and a rise in

SUBMITTER: Leardini D 

PROVIDER: S-EPMC12672365 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature