Selective direct influence of motor cortex on limb muscle activity during naturalistic climbing in mice.

ABSTRACT: When and how motor cortical output directly influences limb muscle activity through descending projections remain poorly resolved, impeding a mechanistic understanding of motor control. Here we addressed this in mice performing an ethologically inspired climbing behavior. We quantified the direct influence of forelimb primary motor cortex (caudal forelimb area) on muscles across the muscle activity states expressed during climbing. We found that the caudal forelimb area instructs muscle activity pattern by selectively activating certain muscles, while less frequently activating or suppressing their antagonists. From Neuropixels recordings, we identified linear combinations (components) of motor cortical activity that covary with these effects. These components differ partially from those t

SUBMITTER: Koh N 

PROVIDER: S-EPMC12672376 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature