Cytokine profile of Post-cardiopulmonary bypass in children.

ABSTRACT:

Background

Open cardiac surgery involving cardiopulmonary bypass (CPB) triggers a systemic inflammatory response that significantly affects clinical outcomes. However, the dynamics and specific roles of cytokine release after CPB in the pediatric population remain unclear.

Purpose

To evaluate the dynamics of cytokine levels and their association with low cardiac output syndrome (LCOS)-related outcomes.

Methods

A prospective observational cohort study was conducted of 32 children who underwent elective open cardiac surgery with CPB at Songklanagarind Hospital, Thailand. Levels of interleukin (IL)-1β, IL-6, IL-8, IL-10, and tumor necrosis factor (TNF)-α were analyzed preoperatively and immediately (T0), 6, 12, and 24 hours after intensive care unit admission. LCOS-relat

SUBMITTER: Saelim K 

PROVIDER: S-EPMC12672401 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature