Association between vitamin D polymorphisms and binding protein and COVID-19 risk and severity in children.

ABSTRACT:

Background

The effects of genetic background on the biological effects of vitamin D on coronavirus disease 2019 (COVID-19) in children remain unclear.

Purpose

This study aimed to explore the association between vitamin D-related genetic background and 25-hydroxyvitamin D status and COVID-19 occurrence and severity in children. Here we explored key genetic variants within the vitamin D pathway in pediatric COVID-19 patients in relation to circulating vitamin D binding protein (VDBP).

Methods

Sixty children aged 0-14 years with severe acute respiratory syndrome coronavirus 2 infection and 60 matched controls were genotyped for the vitamin D receptor (VDR) gene (FokI, BsmI, TaqI, ApaI), Gc gene of VDBP (rs7041, rs4588), and CYP27B1 promoter (rs10877012) single nucleotide

SUBMITTER: Giatraki V 

PROVIDER: S-EPMC12672402 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature